professor Chi-Yuan Hong

Ph.D. in Dental Prosthodontics and Oral Biology, Harvard University, USA

1. Tissue reaction of Polysulfone in Macaca Cyclopsis.
2. Improved metal etching by using potential static device.
3. The induction of bone growth by using Calcium Phosphate Cement (CPC).
4. Tissue reaction of Polysulfone in TMjoint of Macaca Cyclopsis.
5. Tissue reaction in extraction socket of Macaca Cyclopsis by using Hydroxylapatite bone substitute.
6. Improve physical properties of Injection type denture base resin.
7. Physical properties of light curing glass ionomer in early contact of water.
8. Effect of base metal castability by using different sprue designs.
9. Physical properties of human bone substitute -- Calcium Phosphate Cement (CPC).
10. A in vitro molecular model for study betel quid biotoxicity.
11. Oral Cancer—Gene Therapy Preclinical Trials via Tumor Suppressor Proteins.
12. Improve Initial stability of Implant for narrow ridge.

1. Lin SK, Kok SH, Shun CT, Hong CY, Wang CC, Hsu MC, Liu CM (2007). Tumor necrosis factor-alpha stimulates the expression of C-C chemokine ligand 2 gene in fibroblasts from the human nasal polyp through the pathways of mitogen-activated protein kinase. Am J Rhinol. Mar-Apr;21(2):251-5.
2. Lin SK, Chang HH, Chen YJ, Wang CC, Galson DL, Hong CY, Kok SH (2008): EGCG diminishes CCL2 expression in human osteoblastic cell via up-regulating PI3K/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis. Arthritis & Rheumatism. 58:3145-56. (co-corresponding Author)
3. Lee YL, Hong CY, Kok SH, Hou KL, Lin YT, Chen MH, Wang CC, Lin SK(2009): An Extract of Green Tea, Epigallocatechin-3-Gallate,Reduces Periapical Lesions by Inhibiting Cysteine-rich 61Expression in Osteoblasts. J Endodont. 35:206-11.
4. Lin SK, Kok SH, Lee YL, Hou KL, Lin YT, Chen MH, Wang CC, Hong CY (2009): Simvastatin as a novel strategy to alleviate periapical lesions. J Endodont. 35:657-62. (corresponding Author)
5. Kok SH, Hong CY , Kuo MY, Wang CC, Hou KL, Lin YT, Galson DL, Lin SK (2009): Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis. Arthritis Rheum. 60:1451-62.
6. Lee YL, Lin SK, Hong CY, Wang JS, Yang H, Lai EH, Chen MH, Kok SH (2010): Major histocompatibility complex class II transactivator inhibits cysteine-rich 61 expression in osteoblastic cells and its implication in the pathogenesis of periapical lesions. J Endodont. 36:1021-5.
7. Kok SH, Hou KL, Hong CY, Wang JS, Liang PC, Chang CC, Hsiao M, Yang H, Lai EH, Lin SK (2011): Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: A therapeutic benefit for arthritis. Arthritis Rheum. 63(4):1010-20.
8. Shun CT, Lin SK, Hong CY, Huang HM, Liu CM (2011): Hypoxia induces cysteine-rich 61, vascular endothelial growth factor, and interleukin-8 expressions in human nasal polyp fibroblasts: An implication of neutrophils in the pathogenesis of nasal polyposis. Am J Rhinol Allergy. 25:15-8.
9. Lai EH, Hong CY, Kok SH, Hou KL, Chao LH, Lin LD, Chen MH, Wu PH, Lin SK(2012): Simvastatin alleviates the progression of periapical lesions by modulating autophagy and apoptosis in osteoblasts. J Endod. 38:757-63.
10. Wu PH, Lin SK, Lee BS, Kok SH, Wang JH, Hou KL, Yang H, Lai EHH, Wang JS, Hong CY (in press): Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis. Rheumatology.. (corresponding Author)